University of Twente, 2 PhD Reversible noncovalent assemblies for in-vivo imaging applications - scholarships-netherlands.blogspot.com

University of Twente, 2 PhD Positions: Reversible noncovalent assemblies for in-vivo imaging applications The assemblies will be investigated for their potential in molecular imaging. Proof-of-concept studies will be focused on the fluorescent visualization of tumor cells, and in tumor models, with as ultimate aim to develop a methodology for in fluorescence guided surgery.

Two PhD students will jointly carry out the development and validation of the self-assembled systems. One PhD student will be employed in the Molecular Nanofabrication (MnF) group (Prof. J Huskens and Dr. W. Verboom) at the University ofTwente (Enschede, the Netherlands). This group has a strong track record in supramolecular chemistry and the assessment of complex stabilities. The other PhD student will be employed in the group of Dr. F.W.B. van Leeuwen housed in the clinical departments of Radiology and Nuclear medicine in the Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital (NKI-AVL; Amsterdam, the Netherlands). The research efforts of this latter group are focused around (interventional) molecular imaging and they currently have ongoing clinical trails wherein they use self-assembled imaging agents for surgical guidance.

Job description:
- The PhD student at UT/MnF will focus on strategies to make well-controlled functional assemblies by supra­molecular methods. This will encompass: (i) assembly formation in solution, in microfluidic systems, and by solid-phase methods (on flat surfaces and on beads), and an assessment of their comparison, and (ii) study of the competition-driven disassembly in solution.
- The PhD student at the NKI-AVL will focus more on the application of the functional-assemblies in biological systems. This will encompass: (i) use of biological triggers to drive the assembly/disassembly process and (ii) study of the assembly/disassembly in vitro and in vivo.

Requirements

For this challenging project the UT/MnF group and the NKI-AVL look for two enthusiastic PhD students who like to work in a multidisciplinary team and in an international environment. For the UT he/she must have excellent knowledge and skills of (physical) organic chemistry and should also have special interest in characterization techniques. The PhD student for the NKI-AVL preferably has a background in chemistry, but good applicants with a pharmaceutical or more biotechnology oriented background are also encouraged to apply.
For information regarding the position at UT/MnF: please contact Prof. dr. ir. J. Huskens / Dr. W. Verboom; e-mail: j.huskensutwente.nl, Tel. +31 (0)53 4892995.


For information regarding the position at the NKI-AVL, please contact Dr. F.W.B. van Leeuwen; e-mail: f.w.b.vanleeuwennki.nl, Tel. +31 (0)20 5126084.
Applications:
Please send your applications, through the application link, before September 5th, 2011.

Conditions of employment

- A PhD position for four years (with an evaluation after the first year)
- A stimulating scientific environment
- Gross salary ranging from € 2042 to € 2612 (4th yr) per month
- Holiday allowance (8%), end-of-year bonus (8.3%)
- Excellent facilities for professional and personal development.
- Good secondary conditions
- A green Campus with lots of sports facilities

Organisation

The University of Twente. We stand for life sciences and technology. High tech and human touch. Education and research that matter. New technology which drives change, innovation and progress in society. The University ofTwente is the only campus university in the Netherlands; divided over six faculties we provide more than fifty educational programmes. The University ofTwente has a strong focus on personal development and talented researchers are given scope for carrying out pioneering research.

Within the TNW Faculty (Faculty of Science & Technology) of the University of Twente some 700 staff members and more than 1100 students are involved in training and research on the interface of chemical technology, applied physics and biomedical technology. Fields of application include sustainable energy, process technology and materials science, nanotechnology and technical medicine. Research, which enjoys a high profile both at home and internationally, has been accommodated in the multidisciplinary research institutes IMPACT, MESA+ and MIRA. The faculty works together intensively with industrial partners and researchers in the Netherlands and abroad and conducts extensive research for external commissioning parties and funders.

To apply for this position, visit AcademicTransfer for the original posting, and many other scientific vacancies.

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